Cancer Horror Stories

JESSE GELSINGER: SACRIFICED TO GREED?

QUESTIONS AND CONCESSIONS

Because of reports about adverse events such as these, two reviewers on the Recombinant DNA Advisory Committee (RAC) who were overseeing the proposed experiment became concerned about the potential risks of Wilson's study.

Indeed, they were so concerned due to the deaths of the animals in his earlier tests that they felt the therapy should not be tested on asymptomatic volunteers and recommended against the trial. Wilson, however was not about to give up. To mollify them, he made certain concessions to the reviewers.

Among them was the concern about how subjects were going to be recruited. Wilson agreed to recruit only through their physicians.

Despite this promise, in 1997, one of Wilson's co-investigators, Mark Batshaw, wrote articles for the National Urea Cycle Disorders Foundation newsletter (the publication of the organization concerned with OTC) recruiting volunteers. The articles also appeared on the group's website. One person who saw them was young Jesse Gelsinger's pediatric geneticist.

It was Batshaw's articles that led Jesse Gelsinger to the Genovo experiment.

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